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ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis.
The ZIKV helicase, which plays a pivotal role in viral RNA replication, is an attractive target for therapy. We determined the crystal structures of ZIKV helicase-ATP-Mn2+ and ZIKV helicase-RNA. This is the first structure of any flavivirus helicase bound to ATP. Comparisons with related flavivirus helicases...
Clinical Procedures (703). Helicase Assays. Authors: Xin Wang Jing Li Jason Diaz Jianxin You. In this protocol, the DNA helicase protein Merkel cell polyomavirus large T-antigen was expressed in the mammalian cell line HEK293 and immoblized on an IgG resin.
FlyBase ID: FBgn0014189. Genetic map position - 2L: 5,539,326..5,542,310 [-]. Classification - DEAD-box helicase. Using RNAi screening, this study found that depletion of the Drosophila DExH/D-box helicase Hel25E results in nuclear accumulation of long (>800-nucleotide), but not short, circRNAs.
RNA helicases are implicated in most cellular RNA-dependent events. In eukaryotes however, only few have been functionally characterized. Upf1 is a RNA helicase essential for nonsense-mediated mRNA decay (NMD). Here, using magnetic tweezers and bulk assays...
Helicase is a homohexamer that encircles the lagging strand like a ring. It translocates along the ssDNA and separate the duplex DNA using energy from ATP hydrolysis. The unwinding of double stranded DNA and discontinuous synthesis of lagging strand leaves Continue Reading →.
Together, our results reveal the structural and functional interplay between two helicase cassettes in a tandem superfamily 2 enzyme and point to several sites Brr2 represents a unique subclass of nucleic acid helicases, containing tandem helicase cassettes expanded by Sec63 homology units, which also...
Helicases and other DNA translocases must travel along crowded substrates. In this issue, Honda et al. (2009) report that the archaeal XPD helicase can (2009) report that the archaeal XPD helicase can bypass a single-stranded DNA-binding protein without either molecule being ejected from the DNA.
Helicase on WN Network delivers the latest Videos and Editable pages for News & Events, including Entertainment, Music, Sports, Science and more, Sign up and share your playlists. The conserved RNA helicase Vasa is required for germ cell development in many organisms ...